Actively Recruiting
MTAP - NCT05094336 AMG 193, Methylthioadenosine (MTA) Cooperative Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, Alone and in Combination With Docetaxel in Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors

Please note, some trial-specific information on this page is sourced from clinicaltrials.gov.

About

Trial summary
TYPE Interventional
PHASE
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Phase

Clinical trials are done in different phases (0-4). Each phase provides important information about the drug. If a drug does not pass a particular phase, it cannot progress to the next phase. Visit the About Clinical Trials page to learn more.

Phase 1
CONDITION
  • Advanced MTAP-null Solid Tumors
  • INTERVENTIONS
    Interventions tooltip icon

    Interventions

    The drug, device, or procedure being tested.

      Drug:AMG 193
      AMG 193: Orally via tablet
      Drug:Docetaxel
      Docetaxel: Intravenous infusion
      Drug:Comparator AMG 193 Test Tablet
      Comparator AMG 193 test tablet: Orally via tablet. Only participants in the DSPS group of the Part 1a, Phase 1: AMG 193 Monotherapy Dose Exploration, and Part 1j, Phase 1 arms will receive comparator AMG 193 test tablet.
    ENROLLMENT
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    Enrollment

    The number of participants needed to take part in this trial.

    527 participants
    (Estimated)
    18 Years to 100 Years
    (Adult, Older Adult)
    LOCATIONS 43
    Key dates
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    Key dates

    When the trial is conducted - from the date the first participant is enrolled to the date of the last participants's final visit.

    February 1, 2022
    Trial start date
    February 27, 2028
    Trial end date (Estimated)
    More Information
    OTHER STUDY IDs
      20210023
    Clinical Trials Gov ID NCT05094336
    Last Updated

    We are currently unable to share site locations for this clinical trial. Please use the link to view (or find) site locations:

    CLINICALTRIALS.GOV

    Results

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    CLINICALTRIALS.GOV
    Contact Us

    Please contact a clinical trial site directly to learn more about the trial. If no contact details are available, or for general inquiries, please contact the Biogen Clinical Trial Center.

    United States Biogen Clinical Trial Center

    866-633-4636

    clinicaltrials@biogen.com

    Find a trial location