Actively Recruiting
MTAP - NCT05094336 AMG 193, Methylthioadenosine (MTA) Cooperative Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, Alone and in Combination With Docetaxel in Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors

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Trial summary
TYPE Interventional
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Clinical trials are done in different phases (0-4). Each phase provides important information about the drug. If a drug does not pass a particular phase, it cannot progress to the next phase. Visit the About Clinical Trials page to learn more.

Phase 1
  • Advanced MTAP-null Solid Tumors
    Interventions tooltip icon


    The drug, device, or procedure being tested.

      Drug:AMG 193
      AMG 193: Orally via tablet
      Docetaxel: Intravenous infusion
      Drug:Comparator AMG 193 Test Tablet
      Comparator AMG 193 test tablet: Orally via tablet. Only participants in the DSPS group of the Part 1a, Phase 1: AMG 193 Monotherapy Dose Exploration, and Part 1j, Phase 1 arms will receive comparator AMG 193 test tablet.
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    The number of participants needed to take part in this trial.

    527 participants
    18 Years to 100 Years
    (Adult, Older Adult)
    Key dates
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    Key dates

    When the trial is conducted - from the date the first participant is enrolled to the date of the last participants's final visit.

    February 1, 2022
    Trial start date
    February 27, 2028
    Trial end date (Estimated)
    More Information
    Clinical Trials Gov ID NCT05094336
    Last Updated

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