Actively Recruiting
AMETHYST - NCT05531565 A Study to Assess the Efficacy and Safety of BIIB059 (Litifilimab) in Participants With Active Subacute Cutaneous Lupus Erythematosus (SCLE) and/or Chronic Cutaneous Lupus Erythematosus (CCLE) With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy

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Trial summary
TYPE Interventional
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Phase 2
  • Subacute Cutaneous Lupus Erythematosus
  • Chronic Cutaneous Lupus Erythematosus
    Interventions tooltip icon


    The drug, device, or procedure being tested.

      Drug:BIIB059 (litifilimab)
      Administered as specified in the treatment arm.
      Administered as specified in the treatment arm.
    Icon tooltip


    The number of participants needed to take part in this trial.

    474 participants
    18 Years and Above
    (Adult, Older Adult)
    Key dates
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    Key dates

    When the trial is conducted - from the date the first participant is enrolled to the date of the last participants's final visit.

    September 13, 2022
    Trial start date
    December 13, 2026
    Trial end date (Estimated)
    More Information


    Clinical Trials Gov ID NCT05531565
    Last Updated

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